Description
CD137L (mouse)
All names and symbols: Tumor necrosis factor ligand superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; CD137 ligand; 4-1BB ligand; 4-1BBL; 4-1BB-L; AI848817; Cd137l; Cd157l; Ly63l; Ly63l
| Host species | Rat |
| Clonality | Recombinant |
| Isotype | IgG1, kappa, recombinant version of clone AT113-2 |
| Confirmed species reactivity | Mouse |
| Confirmed applications | blocking |
| Aeonian Rating® | 85 |
| RRID | AB_2904499 |
Biological Activity
Neutralizing CD8+ T cells through mature dendritic cells:
The original clone AT113-2 was successfully used to prevent dendritic cells from activating CD8+ T cells in mouse splenocytes.
French RR, Taraban VY, Crowther GR, Rowley TF, Gray JC, Johnson PW, Tutt AL, Al-Shamkhani A, Glennie MJ. Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation. Blood. 2007 Jun 1;109(11):4810-5. doi: 10.1182/blood-2006-11-057216. PMID: 17311995.
| Expiration | Integrity warranted for 24 months after purchase when handled and stored according to instructions, see below. |
| Storage instructions | Avoid repeated freeze/thaw cycles. For long term storage, keep small aliquots at -20°C or -80°C and keep one aliquot at 4°C for daily experimentations. Azide will preserve antibody at 4°C for 6-12 months, when kept away from direct sun light. |
| Warranty | This product is only warranted for the specifications as described in this product sheet and only when the product is handled and stored according to instructions. User should validate this antibody in the application and tissue/cell type as required, after confirmation of integrity upon receipt is obtained by reproducing the performance as described below. Should such confirmation not be attempted, any warranty is void. In case of non-conformance, user needs to contact us immediately for replacement or refund. |
| Liability | This product is for in vitro research use only. Any other applications, such as diagnostics or therapeutics, or in vivo experiments, and the validation of this product therein, are solely at the responsibility of the buyer/user. |
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