Description
CD147
All names and symbols: Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; Hepatoma-associated antigen; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; 5F7; Basigin; BSG; CD147; EMPRIN; EMMPRIN; EOK; HAb18G
| Host species | Mouse |
| Clonality | Recombinant |
| Isotype | IgG1, kappa, new chimeric version of recombinant clone Ab-1 |
| Confirmed species reactivity | Human |
| Confirmed applications | Blocking |
| Aeonian Rating® | 90 |
| RRID | AB_2909611 |
Biological Activity
Blocking PfRH5–CD147 interaction:
The original clone Ab-1 was successfully used to block the interaction between the erythrocyte receptor CD147 (Basigin) and the PfRH5 ligand of parasite Plasmodium falciparum (causing malaria).
Zenonos ZA, Dummler SK, Müller-Sienerth N, Chen J, Preiser PR, Rayner JC, Wright GJ. Basigin is a druggable target for host-oriented antimalarial interventions. J Exp Med. 2015 Jul 27;212(8):1145-51. doi: 10.1084/jem.20150032. PMID: 26195724.
Ab-1-specific most recent literature
Shilts J, Crozier TWM, Greenwood EJD, Lehner PJ, Wright GJ. No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor. Sci Rep. 2021 Jan 11;11(1):413. doi: 10.1038/s41598-020-80464-1. PMID: 33432067.
Ulrich H, Pillat MM. CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement. Stem Cell Rev Rep. 2020 Jun;16(3):434-440. doi: 10.1007/s12015-020-09976-7. PMID: 32307653.
Galaway F, Yu R, Constantinou A, Prugnolle F, Wright GJ. Resurrection of the ancestral RH5 invasion ligand provides a molecular explanation for the origin of P. falciparum malaria in humans. PLoS Biol. 2019 Oct 15;17(10):e3000490. doi: 10.1371/journal.pbio.3000490. PMID: 31613878.
Aniweh Y, Gao X, Hao P, Meng W, Lai SK, Gunalan K, Chu TT, Sinha A, Lescar J, Chandramohanadas R, Li HY, Sze SK, Preiser PR. P. falciparum RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC. Cell Microbiol. 2017 Sep;19(9). doi: 10.1111/cmi.12747. Epub 2017 May 9. PMID: 28409866.
| Expiration | Integrity warranted for 24 months after purchase when handled and stored according to instructions, see below. |
| Storage instructions | Avoid repeated freeze/thaw cycles. For long term storage, keep small aliquots at -20°C or -80°C and keep one aliquot at 4°C for daily experimentations. Azide will preserve antibody at 4°C for 6-12 months, when kept away from direct sun light. |
| Warranty | This product is only warranted for the specifications as described in this product sheet and only when the product is handled and stored according to instructions. User should validate this antibody in the application and tissue/cell type as required, after confirmation of integrity upon receipt is obtained by reproducing the performance as described below. Should such confirmation not be attempted, any warranty is void. In case of non-conformance, user needs to contact us immediately for replacement or refund. |
| Liability | This product is for in vitro research use only. Any other applications, such as diagnostics or therapeutics, or in vivo experiments, and the validation of this product therein, are solely at the responsibility of the buyer/user. |
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