Cancer Related Antibodies - Aeonian Biotech

Our catalogue is primarily focussed on cancer research. We offer:

All of our antibodies have undergone thorough quality control with the use of our proprietary Aeonian Rating® which acts as a quality standard. By referring to our rating you will get a better understanding of the antibody performance. Our Aeonian Rating® will see to it that no matter the cancer-related signalling pathway you may be interested in, you can rest assured that the antibodies meet the expectations in your application.

We offer antibodies based on selectivity: they do not cross-react to closely related non-targets. Part of our antibody range demonstrates selectivity by native protein array. These arrays contain genome-wide human proteins, including those closely related to the target. When the antibody strongly binds to the target and not to other members of the same protein family, selectivity of the antibody is established (see illustration). This adds value to the staining in IHC and ICC.

AE00264 on protein array — Specificity and selectivity of AE00264 to CDH1 were tested against >19,000 full-length human proteins on a human protein array. A protein BLAST search against H. sapiens revealed the following closely related other proteins: Cadherins 2 and 3. These were part of the array used and showed no cross-reactivity signals.

IHC of human breast carcinoma stained with CDH1 Mouse Monoclonal Antibody AE00264 — AE00264 to CDH1 was successfully used to stain plasma membranes in human breast carcinoma sections. Recommended concentration: 0.3-1ug/ml

Part of our IHC range has been validated in Tissue MicroArray (category TVRA-Tissue microarray-Validated Recombinant Antibodies). They confirm specific signals in the correct tissues, and in the correct cancer types. Furthermore, they confirm the lack of signals in tissues and cancer types where no signal is expected! These products come with tables to summarise the tissue microarray results (see illustration).

IHC of human oncocytoma stained with CDH16 Rabbit Recombinant Antibody AE00345 — AE00345 to CDH16 was successfully used to stain membranes in epithelial cells of convoluted tubules (very strong in distal ones) in human healthy kidney sections, and membranes of oncocytoma and renal carcinoma sections. Recommended concentration: 1-3ug/ml.

Cancer Tissue MicroArray IHC signals from AE00345 to CDH16.

We offer a select group of functional recombinant antibodies that either inhibit or stimulate signalling. See illustration

ICC of Jurkat stained with CD137 Rabbit Recombinant Antibody AE00311 — AE00311 to CD137 was successfully used to stain the cellular surface of cell line Jurkat. Recommended concentration: 10 ug/ml.

Biological activity of AE00311 to CD137 on lymphocytes and monocytes.

Product	Host	Reactivity	Applications	Aeonian Rating®	Product page
CD137L Recombinant Antibody AE00317	Rabbit	Mouse	blocking , FC	100	See details
CD146 Monoclonal Antibody AE00285	Mouse	Human	IHC , protein array (native)	83	See details
CD147 Recombinant Antibody AE00327	Mouse	Human	blocking	90	See details
CD1a Recombinant Antibody AE00348	Mouse	Human	IHC	90	See details
CD21 Monoclonal Antibody AE00164	Mouse	Human	IHC , protein array (native)	85	See details
CD21 Monoclonal Antibody AE00269	Mouse	Human	IHC , protein array (native) , WB	85	See details
CD22 Recombinant Antibody AE00354	Rabbit	Human	IHC	92	See details
CD27 Monoclonal Antibody AE00205	Mouse	Human	ICC , IHC , protein array (native)	80	See details
CD276 Recombinant Antibody AE00323	Rat	Mouse	enhancement CD8+ T-cell tumour infiltration , FC , inhibition CD4+ T-cell proliferation	90	See details
CD276 Recombinant Antibody AE00324	Rabbit	Mouse	ELISA , enhancement CD8+ T-cell tumour infiltration , FC , inhibition CD4+ T-cell proliferation	90	See details

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