MSH6 Recombinant Antibody AE00380

520,001.500,00

Specific, and tissue microarray-validated rabbit recombinant antibody clone AE906R to human MSH6

See all our MSH6 antibodies

Official Symbol: MSH6

GeneID: 2956

Swiss-Prot: P52701

For BSA-free at 1mg IgG/ml, please ask us for a quotation.

Description

MSH6

All names and symbols: DNA mismatch repair protein Msh6; G/T mismatch-binding protein ; MutS-alpha 160 kDa subunit (p160); MutS protein homolog 6; GTBP; GTMBP; HNPCC5; HSAP; hMSH6; MSH-6; MMRCS3; p160

Host speciesRabbit
ClonalityRecombinant
IsotypeIgG
Confirmed species reactivityHuman
Confirmed applicationsIHC
Aeonian Rating®92
RRIDAB_2924705

Immunohistochemistry (IHC):

AE00380 to MSH6 was successfully used to stain nuclei in normal esophagus and skin sections, and in ovarian endometriod carcinoma sections. Recommended concentration: 1-3 μg/ml

IHC of human esophagus stained with MSH6 Rabbit Recombinant Antibody AE00380
Human esophagus with AE00380

Formaldehyde-fixed, paraffin-embedded human esophagus stained with MSH6 Rabbit Recombinant Antibody AE00380 at 1-2 μg/ml for 60 minutes at 37°C. Epitope retrieval: Autoclave at 121°C, pH7.8 for 5 min followed by 20 min cooling. DAB staining by HRP polymer.

IHC of human skin stained with MSH6 Rabbit Recombinant Antibody AE00380
Human skin with AE00380

Formaldehyde-fixed, paraffin-embedded human skin stained with MSH6 Rabbit Recombinant Antibody AE00380 at 1-2 μg/ml for 60 minutes at 37°C. Epitope retrieval: Autoclave at 121°C, pH7.8 for 5 min followed by 20 min cooling. DAB staining by HRP polymer.

IHC of human ovarian endometrioid carcinoma stained with MSH6 Rabbit Recombinant Antibody AE00380
Human ovarian endometrioid carcinoma with AE00380

Formaldehyde-fixed, paraffin-embedded human ovarian endometrioid carcinoma stained with MSH6 Rabbit Recombinant Antibody AE00380 at 1-2 μg/ml for 60 minutes at 37°C. Epitope retrieval: Autoclave at 121°C, pH7.8 for 5 min followed by 20 min cooling. DAB staining by HRP polymer.

Tissue Microarray Validation:

Normal tissues

Strong positiveWeak to moderateNo staining at all
adrenal glandappendix muscular walladipose
appendix mucosacerebellumaorta media
bone marrowcerebrum
breastcolon muscular wall
bronchus mucosagallbladder
colon mucosaheart muscle
duodenum Brunner glandlung
duodenum mucosapituitary gland posterior lobe
endocervixskeletal muscle
ectocervixurinary bladder muscular wall
endometrium, proliferation
endometrium, secretion
epididymis
esophagus squamous epithelium
fallopian tube
ileum mucosa
liver
lymph node
myometrium
ovarian stroma
pancreas
parathyroid gland
parotid gland
pituitary gland anterior lobe
placenta
prostate
rectum mucosa
renal cortex
renal medulla
seminal vesicle
sinus paranasalis
skin
spleen
stomach
testis
thymus
thyroid gland
tonsil
urothelium

Cancer tissues

Strong positiveWeak to moderateNo staining at all
breast cancer no special typeclear cell ovarian carcinoma
colorectal adenocarcinomapancreas ductal adenocarcinoma
gastric adenocarcinomaprostate adenocarcinoma
high-grade serous carcinoma
lung adenocarcinoma
Mullerian ovary tumor
Mullerian uterus tumor
ovarian endometrioid carcinoma
pancreas acinar cell carcinoma
ExpirationIntegrity warranted for 24 months after purchase when handled and stored according to instructions, see below.
Storage instructionsAvoid repeated freeze/thaw cycles. For long term storage, keep small aliquots at -20°C or -80°C and keep one aliquot at 4°C for daily experimentations. Azide will preserve antibody at 4°C for 6-12 months, when kept away from direct sun light.
WarrantyThis product is only warranted for the specifications as described in this product sheet and only when the product is handled and stored according to instructions. User should validate this antibody in the application and tissue/cell type as required, after confirmation of integrity upon receipt is obtained by reproducing the performance as described below. Should such confirmation not be attempted, any warranty is void. In case of non-conformance, user needs to contact us immediately for replacement or refund.
LiabilityThis product is for in vitro research use only. Any other applications, such as diagnostics or therapeutics, or in vivo experiments, and the validation of this product therein, are solely at the responsibility of the buyer/user.
Product Data Sheet
Material Safety Data Sheet

Additional information

Purification

By Protein A from bioreactor concentrate

Immunogen

Recombinant N-terminal fragment within aa 1-100 region of human MSH6 protein (exact sequence is proprietary)

Epitope

N-terminal region (within aa 1-100)

Cellular localization

nucleus

Positive Controls

esophagus, ovarian carcinoma, skin

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